晚发型重症肌无力的临床研究

目的 观察晚发型（≥50岁）重症肌无力（MG）的临床特点及治疗。方法 53例MG患者，其中晚发型29例（54.7％），29例均做EGM、AchR-Ab、胸腺CT及X线检查；分别给予皮质激素药物、大剂量免疫球蛋白（IVIG）和新斯的明类药物治疗。29例中男性16例，女性13例，平均年龄64.4(50-83）岁。结果 分型以轻型为多，占75.8%，无胸腺瘤证据，AchR-Ab阳性率36.3％。三组治疗以IVIG＋新斯的明组疗效好（P＜0.01），激素 治疗组不良反应大。结论 晚发型MG发病在增加，此型胸腺瘤少见，以新斯的阴＋IVIG治疗效果好，并发症少。

Clinical observation of late-onset myasthenia gravis

Objective　To observe clinical features of late-onset myasthenia gravis(MG) and explore its treatment.Methods　The EMG,AchR-Ab and CT or X-ray of thymus were taken for 29 cases of late-onset MG with a mean age of 64.4 (50～83) years old and 16 males and 13 females.Corticoid,IVIG+anticholinesterases and anticholinesterases were used respectively by three groups.Results　The incidence of late-onset MG was 54.7% (29/54).The mild type of MG was in majority (75.8%).There was no evidence of thymus tumor.IVIG+anticholinesterases was the best therapy in the three groups (P＜0.01) and side effect of corticoid was prominent.Conclusions　Incidence of late-onset MG is increased.IVIG+anticholinesterses is a good therapy for late-onset MG.