格列齐特药物治疗下2型糖尿病患者血糖控制水平影响因素研究

目的探讨格列齐特药物治疗下2型糖尿病患者血糖控制水平的影响因素的相互关系和作用大小。方法该研究为多中心研究,选择北京、汕头两地符合纳入标准的糖尿病患者,调查基线资料。按照给药方案进行为期60d的格列齐特药物治疗,并每周进行随访,收集随访资料。基线调查包括人口学资料、生活习惯、身高、体重等。随访资料包括药物依从性,空腹血糖、餐后血糖等。采用SPSS16.0和AMOS7.0进行数据分析。结果最终进入多重线性模型的变量为:第1天空腹血糖水平、低血糖次数、体育锻炼情况、饮食控制情况。各变量标准化回归系数分别为:0.479,-0.093,-0.089,-0.086。通径分析显示,模型经检验拟合良好,第1天空腹血糖水平、饮食控制情况、体育锻炼情况、低血糖次数、药物依从性对于第57天空腹血糖水平的总效应分别为0.481,-0.084,-0.080,-0.093,-0.004。结论加强饮食控制和体育锻炼、减少低血糖发生次数、提高药物依从性有助于提高2型糖尿病患者空腹血糖控制水平。而提高药物依从性可减少低血糖发生次数。基线空腹血糖水平较低有利于提高后期血糖控制水平,减少低血糖发生次数。

The Influential Factors of Fasting Blood Glucose in Patients of Type 2 Diabetes Mellitus with Gliclazide Treatment

Objective To discuss the influential factors of fasting blood glucose （FBG） in patients of type 2 diabetes mellitus（T2DM ） with Gliclazide treatment. Methods The study was a muhicenter study. Patients of T2DM who met the inclusion criteria were collected from Beijing and Shantou and were investigated on the baseline information. Then all patients were given the Gliclazide treatment （30 mg/d） for a period of 60 days and followed-up once every week. The baseline survey included demographic data, such as habits, height, weight, and so on. Follow-up data included medication compliance, FBG, postprandial blood glucose. SPSS 16.0 and AMOS 7.0 were used in data analysis. Results The variables which included in the final multiple linear model were as follows： FBG level in the first day, the attack times of hypoglycemia, the condition of physical exercise and the condition of diet control, and the standardized regression coefficients of the variables above were： 0.479, -0.093, -0.089 and -0.086, respectively. Pathway analysis showed that the effects of FBG level in the first day, the condition of diet control, the condition of physical exercise the attack times of hypoglycemia and the compliance to the drug on FBG level in the 57^thday were 0.481, -0.084, -0.080, -0.093 and -0.004, respectively. Conclusion It could help to enhance the control of FBG level among T2DM patients by strengthening diet control and physical exercise, reducing the attack time of hypoglycemia, and improving medication compliance. To improve medication compliance could reduce the occurrence of hypoglycemia.