空腹血糖受损人群血清C反应蛋白表达及临床意义探讨

目的探讨空腹血糖受损人群(IFG)C反应蛋白表达及其意义。方法对中国医科大学附属第一医院2005-03～09期间就诊病人行口服葡萄糖75g耐量试验(OGTT)分析,以诊断IFG28例(男16例、女12例)为观察组,IFG正常者30例为对照组(男17例、女13例)。采用酶联免疫吸附法(ELISA)测定血清C反应蛋白(CRP)表达。结果(1)IFG者血清CRP表达明显高于正常者,并且差异有显著性(P<0.01)。(2)血清CRP表达与空腹血糖(FPG)(r=0.56,P<0.01)、OGTT糖负荷后血糖(2hPBG)(r=0.66,P<0.01)、糖化血红蛋白(HbA1c)(r=0.37,P<0.05)、甘油三酯(TG)(r=0.29,P<0.05)、稳态模型分析法(HOMA)-IR(r=0.38,P<0.05)呈正相关,与高密度脂蛋白(HDL)(r=-0.24,P<0.05)呈负相关,与体重指数(BMI)、胆固醇(TC)等指标的相关性不显著。结论IFG人群已出现炎症表现。CRP在2型糖尿病和动脉粥样硬化的发生发展中起着重要的作用。

Serum C-reactive protein levels in subjects with impaired fasting glycemia and its clinical significance

Objective To investigate the levels of serum C-reactive protein in subjects with impaired fasting glycemia and its significance.Methods From Mar.to Sep.2005,according to oral 75 g glucose tolerance test(OGTT)in the patients in the First Hospital Affiliated to China Medical University,there are 30 subjects with normal glucose tolerance(NGT),28 cases with impaired fasting glycemia(IFG).CRP was detected with ELISA.Results (1)Serum CRP in the subjects with impaired fasting glycemia was significantly higher than those in normal subjects( P<0.01).(2)The serum CRP was positively correlated with FPG(r=0.56,P<0.01),OGTT 2 h blood glucose(r=0.66,P<0.01),HbA_1c(r=0.37,P<0.05),triglyceride(TG)(r=0.29,P<0.05),HOMA-IR(r=0.38,P<0.05).The serum CRP was negatively correlated with HDL(r=-0.24,P<0.05).Conclusion An early stage of inflammation is present in the patients with IFG.CRP plays a role in the initiation and development of type 2 DM and atherosclerosis.