Hemophilia Growth and Development Study: Baseline Neurodevelopmental Findings |
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| Authors: | Loveland, Katherine A. Stehbens, James Contant, Charles Bordeaux, Janice D. Sirois, Patricia Bell, Terece S. Hill, Suzanne Scott, Anthony Bowman, Mary Schiller, Marilyn Watkins, John Olson, Roberta Moylan, Patricia Cool, Valerie Belden, Brain |
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| Affiliation: | University of Texas Medical School Houston, University of Iowa College of Medicine, Baylor University School of Medicine, University of Texas Medical School Houston, Tulane University Medical Center, Children's Hospital Los Angeles, Tulane Medical School, University of Texas Health Science Center San Antonio, University of Oklahoma Health Science Center, Mt. Sinai Medical Center New York, Stanford University Medical School, University of Oklahoma Health Science Center, Wayne State Medical School, University of Iowa College of Medicine, The Children's Mercy Hospital Kansas City, Missouri 2All correspondence should be sent to Katherine A. Loveland, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, UTMSI, 1300 Moursund Street, Houston, Texas 77030 |
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| Abstract: | Reported baseline findings from the neurological assessmentcomponent of the Hemophilia Growth and Development Study (HGDS).HIV-positive (HIV+ n = 207) and HIV-negative (HIV; n= 126) young males with hemophilia ages 6 to 18 years, wereenrolled in a prospective study of their growth and development.At baseline, HIV+ and HIV subjects were not significantlydifferent in test performance. The number of subjects exhibitingbelow-average performance in three or more areas assessed wasabout 25% overall. For both groups, mean test scores were withinthe average range. Academic and adaptive skills were lower thanexpected based on mean IQ scores, and more behavioral/emotionalproblems than expected were reported by parents. Absolute CD4cell counts per mm3 were not related to neuropsychological performanceat baseline. Results suggest that the subjects with HIV wererelatively free of HIV-related neuropsychological impairmentat baseline and that observed differences from a general populationreflect effects of hemophilia as a chronic illness |
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| Keywords: | HIV hemophilia neuropsychology adjustment. |
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