Effect of brain cortex phospholipids on catechol-amine content of mouse brain. |
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| Authors: | G Toffano A Leon D Benvegnu E Boarato G F Azzone |
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| Institution: | 1. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada;2. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada;3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada |
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| Abstract: | Endovenously administered sonicated liposomes of cerebral phospholipids (BC-PL) produce a rapid decrease of catecholamines, nor-epinephrine (NE) and dopamine (DA) in mouse brain. The parallel increase of homovanillic-acid (HVA) results in a shift in DA/HVA ratio, which is an indication of an increased cerebral catecholamine turnover. Phosphatidylserine (PS) is the most active component of BC-PL mixture. |
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