PSCA rs2294008基因变异对膀胱癌分级、分期的影响

目的研究 PSCA rs2294008多态性是否与膀胱癌易感性相关.方法抽取235例膀胱癌患者和200例非膀胱癌患者的血样,进行基因型测定,确定患者血样中 PSCA rs2294008基因型,进行病例对照研究.结果 rs2294008的基因型 CC、CT 和 TT 在膀胱癌患者中出现的概率分别为42．1％、47．7％、10．2％,在对照组中分别为52．0％、40．0％、8．0％；合并的 CT/TT 和 CC基因型对比,合并基因型使膀胱癌风险显著增加(CT/TT：OR＝1．37,95％CI 1．08~1．74).结论PSCA中 rs2294008的基因多态性与膀胱癌的风险相关.

Genetic variant as a selection marker in PSCA and bladder cancer susceptibility

Objective To investigate the association between the prostate stem cell antigen (PSCA)rs2294008 and bladder cancer. Methods We conducted a hospital-based case-control study of 235 cases and 200 controls.We genotyped the rs2294008 polymorphism and assessed its associa-tion with risk of bladder cancer. Results The genotype of rs2294008 is CC,CT,and TT.In case group,the occurrence probability is 42.1%,47.7%,10.2%,and in control group,the occurrence probability is 52.0%,40.0%,8.0%.A significant increased risk of bladder cancer was found for rs2294008 CT/TT genotypes (adjusted odds ratio,1.37;95% confidence interval,1.08-1.74)com-pared with the CC genotype. Conclusions These results indicated that the rs2294008 polymor-phism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a bio-marker for genetic susceptibility to bladder cancer.