转甲状腺蛋白在重度子痫前期及胎儿生长受限孕妇血清中的表达及意义

目的:探讨转甲状腺蛋白(TTR)与s PE及FGR发病的关系及意义。方法:选取2012年9月1日至2015年2月1日在首都医科大学附属北京潞河医院产检并住院分娩的单胎孕妇120例,将患者分为4组:FGR组、s PE组、s PE+FGR组和对照组(各30例)。ELISA法检测TTR浓度。比较4组患者的年龄、孕次、产次、孕周、母血清TTR浓度等指标。结果:4组患者的年龄、孕次、产次、孕周等比较,差异无统计学意义(P0.05)。FGR组、s PE组及s PE+FGR组的母血TTR浓度较对照组明显降低,差异有统计学意义(P0.01)。s PE组血清中TTR含量低于FGR组,差异有统计学意义(P0.01)。结论:TTR在s PE、FGR和s PE+FGR孕妇血清中表达下调,有望成为s PE及FGR发生的生物标志物。s PE合并FGR可能由s PE本身的病理变化引起,s PE与FGR有着共同的病理基础。

Expression and significance of serum transthyretin in severe preeclampsia in combination with fetal growth restriction

Objective:To investigate the transthyretin ( TTR ) level in maternal serum in patients with severe preeclampsia ( sPE) with and without fetal growth restriction ( FGR) . Methods:The TTR level in maternal serum was measured using enzyme-linked immunosorbent assay ( ELISA) in 120 pregnant women from Beijing Luhe hospital during Sep. 2012 to Feb. 2015. Four groups were classified as follows:severe preeclampsia (sPE group,n=30),fetal growth restriction (FGR group,n=30),severe preeclampsia in combination with fetal growth restriction (sPE+FGR group,n=30),and healthy pregnant women (control group,n=30). Ma-ternal clinical data included age, gravity, parity and gestational age were analyzed. Results:There was no significant differences with age,gravity,parity and gestation age among the four groups. Serum TTR levels in sPE group,FGR group and sPE+FGR group were lower than that control group (P<0. 01). Furthermore,serum TTR levels in sPE group were significantly lower compared with the FGR group ( P<0 . 01 ) . Conclusions:TTR levels were significantly lower in pregnant women with sPE,FGR and sPE+FGR,and it may be used as a potential biomarker of sPE and FGR. Thus, fetal growth restriction may share the same pathological mechanism with preeclampsia.