人工黄体期促排卵在卵巢储备功能低下患者中的应用

目的:比较微刺激方案与人工黄体期促排卵方案在卵巢储备功能低下患者体外受精-胚胎移植(l VF-ET)周期中的应用效果,探讨人工黄体期促排卵在卵巢储备功能低下患者中的价值。方法:回顾分析2014年4月至2015年3月在焦作市妇幼保健院生殖中心行IVF助孕的210周期,比较氯米芬微刺激方案组和人工黄体期促排卵方案组的一般资料、促排卵情况、获卵数、取消周期率、2PN率、可利用胚胎率及冷冻胚胎移植妊娠结局等。结果:两组患者的年龄、基础FSH水平及窦卵泡数等比较,差异无统计学意义(P0.05)。与微刺激组比较,人工黄体期促排卵组的Gn天数及Gn总量较多,差异有统计学意义(P0.05)。人工黄体期促排卵组的HCG日E2及P水平均明显高于微刺激组,而LH水平明显低于微刺激组,差异均有统计学意义(P0.05)。人工黄体期促排卵组的获卵数及优胚数较微刺激组多,差异有统计学意义(P0.05)。两组胚胎解冻后妊娠率无明显差异(P0.05)。结论:对于卵巢储备功能低下的患者,人工黄体期促排卵方案可取得较高的获卵数及可利用胚胎数,解冻移植后可获得较满意的临床妊娠结局,提示人工黄体期促排卵方案可为卵巢储备功能低下的患者争取更多的妊娠时机。

Effect of artificial luteal-phase ovarian stimulation protocol in patients with diminished ovarian reserve

Objective:To compare the effects of micro-stimulation and artificial luteal-phase ovulation induction in in vitro fertilization-embryo transfer( IVF-ET) of patients with di-minished ovarian reserve,explore the value of artificial luteal-phase ovarian stimulation protocol in patients with diminished ovarian reserve. Methods:The retrospective analysis 210 cycles with micro-stimulation or artificial luteal-phase ovarian stimulation protocol in Maternal and Child Care Hospital of Jiaozuo city from Apr. 2014 to Mar. 2015. The basic situations and controlled ovarian hyperstimulation ( COH ) of IVF-ET in the two groups were compared, Oocytes re-trieved,normal fertilization rate, top-quality embryo rate and pregnancy outcomes were ana-lyzed. Results:The basic situations in two Group were no significant difference (P>0. 05). Compared with micro-stimulation protocol group,the total and days of gonadotropin used were more in artificial luteal-phase protocol group(P<0. 05). Estradiol(E2) and progesterone(P) levels on the HCG day were significantly higher in artificial luteal-phase group but LH levels on the HCG day were significantly lower(P<0. 05). The oocytes retrieved and superior embryo in artificial luteal-phase group were significantly more than those in micro-stimulation group ( P<0 . 05 ) . pregnancy rate when thawed embryo transfer in two Group were no significant difference ( P>0 . 05 ) . Conclusions:Artificial luteal-phase ovarian stimulation protocol in patients with di-minished ovarian reserve is more likely to achieve more pregnancy times.