| KGF在前列腺癌中的表达及其意义 |
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| 引用本文： | 邱建新,邵国兴,保庭毅,赵致广,杨增悦.KGF在前列腺癌中的表达及其意义[J].中国误诊学杂志,2005,5(4):612-614. |
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| 作者姓名： | 邱建新 邵国兴 保庭毅 赵致广 杨增悦 |
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| 作者单位： | 1. 第四军医大学唐都医院泌尿外科,陕西,西安,710038
2. 第四军医大学西京医院泌尿外科,陕西,西安,710038 |
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| 摘 要： | 目的:探讨角质细胞生长因子(KGF)在前列腺癌中表达的临床意义。方法:应用半定量RT- PCR技术和免疫组织化学方法,检测2 2例前列腺癌组织中KGF的表达,并与正常的前列腺组织进行比较。结果:前列腺癌组织中的KGF表达高于正常的前列腺组织(P<0 .0 5 ) ;KGF表达升高的程度与Pca病理分级和临床分期均无明显关系。结论:前列腺癌组织中KGF的表达高于正常前列腺组织,提示KGF与Pca的发生发展密切相关。
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| 关 键 词： | KGF 前列腺癌 表达 免疫组织化学 |
| 文章编号： | 1009-6647(2005)04-0612-03 |
| 修稿时间： | 2004年12月28 |
The Expression of Keratinocyte Growth Factor (KGF)and Its Significance in Prostatic Carcinoma Tissues |
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| QIU Jian-xin,SHAO Guo-xing,BAO Ting-yi,ZHAO Zhi-guang,YANG Zeng-yue.The Expression of Keratinocyte Growth Factor (KGF)and Its Significance in Prostatic Carcinoma Tissues[J].Chinese Journal of Misdiagnostics,2005,5(4):612-614. |
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| Authors: | QIU Jian-xin SHAO Guo-xing BAO Ting-yi ZHAO Zhi-guang YANG Zeng-yue |
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| Abstract: | Objective:To investigate the clinical significance of keratinocyte growth factor expression(KGF) in prostatic carcinoma tissues.Methods:The expression levels of KGF in 22 sample of prostatic carcinoma tissues and normal prostate tissues were detected by semi-quantitive RT-PCR immunohistochemical staining.Results:The expression levels of KGF in prostatic carcinoma tissues were higher than those in normal prostate tissues (P<0.05). There was no significant correlation between the increased expression of KGF and the pathologic grading as well as clinical stages of Pca.Conclusion:The expression of KGF in Pca tissues was higher than those in nomal prostate tissues. KGF was closely involved in the genesis and developmentr of Pca. |
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| Keywords: | Fibroblast growth factors/metabolism Prostatic carcinoma/pathology Prostatic carcinoma/surgery |
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