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Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix |
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| Authors: | Harry J Gould III Paige R Miller Samantha Edenfield Kelly Jean Sherman Chad K Brady Dennis Paul |
| Institution: | 1.Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA;2.Oleander Medical Technologies, Baton Rouge, LA 70803, USA; (P.R.M.); (D.P.);3.Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA; (S.E.); (K.J.S.);4.Department of Radiology, West Virginia University Medical School, Morgantown, WV 26506, USA; |
| Abstract: | Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas. |
| Keywords: | targeted osmotic lysis advanced-stage cervical cancer sodium channels sodium pumps |