The Ratio of Plasma Interleukin-18 Is a Sensitive Biomarker for Acute Kidney Injury After Liver Transplantation |
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| Authors: | W-C Sung H-P Yu Y-F Tsai PC-H Chung C-C Lin W-C Lee |
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| Institution: | 1. Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan;2. College of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan;3. Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan;4. Division of Transplantation and Liver Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan |
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| Abstract: | BackgroundAcute kidney injury (AKI) is common after liver transplantation (OLT) and is associated with high morbidity and mortality. Previous studies have shown that interleukin-18 (IL-18) levels are associated with AKI. The purpose of this study was to determine whether plasma IL-18 levels were early predictors for AKI after liver transplantation.MethodsPlasma samples were obtained from 26 patients who underwent OLT at induction of anesthesia (T1), 1 hour after the surgical incision (T2), the time of reperfusion (T3), as well as 1 (T4), 2 (T5), and 4 hours (T6) after reperfusion. Samples were also obtained at 24 hours after surgery (T7). The AKI criteria were taken according to the Acute Kidney Injury Network criteria.ResultsTwelve patients (46%) developed AKI after OLT. The area under the receiver operating curve of plasma IL-18 concentrations (T4/T1) to predict AKI occurrence was 0.842 at T5, 0.905 at T6, 0.726 at T7, and 0.726 at T5 to T7.ConclusionPlasma IL-18 concentrations taken 1 hour after reperfusion were predictive of AKI. Therefore, changing IL-18 ratio may be an early predictor for AKI after OLT. |
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