白细胞介素8及皮质醇含量变化与特发性早产的关系

目的探讨白细胞介素8(IL-8)及皮质醇含量的变化及其与特发性早产的关系.方法采用酶联免疫吸附(ELISA)法,检测35例特发性早产孕妇(早产组)及17例同期正常孕妇(对照组)血清和尿液中IL-8含量,并用放射免疫法检测血清中皮质醇含量.结果早产组孕妇血清、尿液中IL-8含量分别为(0.26±0.13)μg/L、(0.16±0.15)×10-2g/mol肌酐,明显高于对照组的(0.16±0.08)μg/L、(0.04±0.02)×10-2g/mol肌酐(P＜0.05,P＜0.01);早产组孕妇血清皮质醇含量为(765.83±408.55)μ/L,明显高于对照组的(512.41±142.65)μg/L(P＜0.01);早产组血清中IL-8与皮质醇含量呈正相关关系(r=0.448,P＜0.05).结论IL-8和皮质醇含量的变化在早产的发病中起着重要作用.

A study of the relationship among interleukin-8, cortisol and idiopathic preterm labor

OBJECTIVE: To assess the effect of interleukin-8 and cortisol on the onset of idiopathic preterm labor (PL). METHODS: In 35 women with preterm labor and 17 controls, maternal serum and urine samples were collected. Interleukin-8 concentration was measured by enzyme-linked immunosorbant assay, serum cortisol level was measured by radioimmunoassay. RESULTS: The concentration of interleukin-8 in maternal serum and urine and cortisol in serum were significantly higher in PL group than those in the control (0.26 +/- 0.13) microg/L vs (0.16 +/- 0.08) microg/L, (0.16 +/- 0.15) x 10(-2) g/mol Cr vs (0.04 +/- 0.02) x 10(-2) g/mol Cr, (765.83 +/- 408.55) microg/L vs (512.41 +/- 142.65) microg/L; P < 0.05, P < 0.01, P < 0.01, respectively]. A strong correlation was found ammong interleukin-8 and cortisol concentration in maternal serum in PL (r = 0.448; P < 0.05). CONCLUSIONS: There is a strong relationship between interleukin-8 and cortisol in the onset of preterm labor. Immune system and endocrine system might be involved in the mechanisms of idiopathic preterm labor.