MSCT灌注成像在肾细胞癌诊断中的应用研究

目的：探讨MSCT灌注成像在肾细胞癌检查中的临床应用。方法：接受16排CT肾脏灌注扫描并行手术切除经病理证实的肾细胞癌患者19例，对比剂为优维显（300mgI/ml）50ml，注药速度4ml/s，经Perfusion 3软件处理后进行综合分析。结果：健侧肾脏与患侧肾脏的正常肾组织同一灌注指标无明显差异（P>0.05），肿瘤实质强化，BF值低于正常肾脏皮质，PS值和肿瘤的恶性程度有关，肿瘤坏死区灌注值降低。结论：MSCT灌注成像实现了肾脏血流的定量研究，直观评价肾癌的微循环变化。

A preliminary study of MSCT perfusion methods in renal cell carcinoma

Objective: To evaluate the application of MSCT perfusion in renal cell carcinoma. Methods: Renal cell carcinoma perfusion was performed in 19 cases with 16 row detector spiral CT, which was confirmed by operation and pathology. Contrast medium(Ultravist 300mg/I) was administered at a dose of 50ml and the rate of injection was 4ml/s. To obtain the perfusion values and maps, data were analyzed by perfusion 3 software. Results: Perfusion value for both sides of the normal kidneys was not obviously different. Compared to normal renal cortex, tumor parenchyma was enhanced obviously and the BF value of tumor was lower. PS value was positively correlated with malignant degree of carcinoma. Perfusion value in the necrotic region of carcinoma decreased significantly. Conclusion: MSCT perfusion image provides quantitative information about renal hemodynamic and could be used to evaluate microcirculation in renal cell carcinoma.