The safety profile of imatinib in CML and GIST: long-term considerations |
| |
Authors: | Eirini Thanopoulou Ian Judson |
| |
Institution: | (1) Royal Marsden NHS Foundation Trust, London, UK |
| |
Abstract: | Imatinib mesylate is considered the standard first-line systemic treatment for patients with chronic myeloid leukaemia (CML)
and gastrointestinal stromal tumour (GIST) by targeting BCR-ABL and c-KIT tyrosine kinases, respectively. Indeed, imatinib
has substantially changed the clinical management and improved the prognosis of both diseases. Treatment with imatinib is
generally well tolerated, and the risk for severe adverse effects is low, generally occurring during the early phase of treatment
and correlating with imatinib dose, phase of disease and patient’s characteristics. This article summarises recent data on
safety profile of imatinib for the treatment of CML and GIST, including long-term side effects. Prolonged treatment with imatinib
in both diseases demonstrates excellent tolerability. There are few significant concerns and those that have emerged, like
cardiotoxicity, have far turned out to be exaggerated. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|