Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination

Authors:	Brigitte Walther David JC Miles Pauline Waight Melba S Palmero Olubukola Ojuola Ebrima S Touray Hilton Whittle Marianne van der Sande Sarah Crozier Katie L Flanagan

Affiliation:	(1) MRC Laboratories Gambia, PO Box 273, Banjul, Gambia;(2) Malawi-Liverpool-Wellcome Trust Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi;(3) Immunisation Department, Health Protection Agency Centre for Infections, London, UK;(4) Department of Pediatrics, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, Bronx, New York, USA;(5) Epidemiology and Surveillance Unit, Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands;(6) Julius Centre, University Medical Centre Utrecht, Utrecht, The Netherlands;(7) MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK

Abstract:	Background Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine challenge.

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