Skp2在骨肉瘤中的表达及临床意义

目的探讨骨肉瘤中Skp2蛋白的表达与患者临床病理和预后的关系。方法用免疫组织化学SP法检测16例骨软骨瘤、12例骨纤维结构不良和48例骨肉瘤组织中Skp2蛋白的表达情况。结果Skp2蛋白在骨软骨瘤和骨纤维结构不良中的表达均为阴性,在骨肉瘤中的表达阳性率为43.75%(21/48),后者的阳性率显著高于前者(P<0.01)。Skp2蛋白表达与临床分期、肺转移及分化程度显著正相关(P<0.05)。结论Skp2可能参与骨肉瘤的发生、发展,检测Skp2蛋白的表达对骨肉瘤患者的早期诊断,判定恶性程度及预后具有指导意义。

Expression of Skp2 in osteosarcoma and there clinical siganificance

Objective To investigate the expression of Skp2 and their association with clinical,histologic characteristics in osteosarcoma. Methods Skp2 protein was examined by using immunohis-tochemical SP staining method in 48 cases of osteosarcoma and 16 cases of osteochondroma, 12 cases offibrous hyperplasia of bone. Results Negative expression of Skp2 was detected in all osteochondroma andfibrous hyperplasia of bone. In contrast, it was detected in 43.75%(21/48)of osteosarcoma. Positive expressionof Skp2 was detected significantly more often in osteosarcoma than that of osteochondroma and fibroushyperplasia of bone(P<0.01). Skp2 protein expression in osteosarcoma was positively associated with theclinical stage, pulmonary metastasis and differentiation(P<0.05). Conclusions Skp2 expression might playan important role in the development and progression of osteosarcoma, and the examination of Skp2expression might be a guide for early diagnosis and a determinant of malignancy and prognosis of osteosarcoma.