电离辐射诱导血管内皮细胞衰老的研究进展

血管内皮细胞（VEC）是位于动脉、静脉和毛细血管内层的单层扁平细胞，对电离辐射（IR）非常敏感。IR不仅可以诱导VEC凋亡还可以诱导其衰老。衰老的VEC表现出多种表型，导致内皮功能障碍。笔者对IR诱导VEC衰老的特征及其相关作用机制和IR诱导衰老VEC在血管疾病中的作用进行综述。

Research progress on vascular endothelial cell senescence induced by ionizing radiation

Vascular endothelial cells (VEC), a single layer of flat cells lines the arteries, veins and capillaries, are sensitive to ionizing radiation (IR). IR is able to induce apoptosis and senescence in VEC. Senescent VEC shows a variety of senescent phenotypes, which further result in endothelial dysfunction. This paper reviews the characteristic of IR-induced VEC senescence, as well as its related functional mechanisms by which IR-induced senescent VEC plays a role in vascular diseases.