| 细胞衰老在眼表疾病中的研究进展 |
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| 引用本文： | 刘江,文杭,项敏泓.细胞衰老在眼表疾病中的研究进展[J].国际眼科纵览,2021,45(1):71-75. |
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| 作者姓名： | 刘江 文杭 项敏泓 |
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| 作者单位： | 上海中医药大学附属普陀医院眼科 200062 |
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| 基金项目： | 国家自然科学基金资助（82074495）；上海市卫生和计划生育委员会科研课题（201840196）；上海市普陀区中心医院英才计划（2017202B） |
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| 摘 要： | 细胞衰老是指细胞生理功能的衰减,包括增生能力下降、细胞周期停滞、细胞凋亡、衰老相关基因表达增加等现象.近年来随着人们对衰老的进一步认识及细胞衰老检测方法的不断补充与升级,为临床治疗衰老相关性疾病提供了新思路和新方法.目前发现眼表的诸多疾病与衰老相关,如干眼症、睑板腺功能障碍、结膜松弛症、Fuchs角膜内皮营养不良、翼状...
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| 关 键 词： | 细胞衰老 眼表疾病 干眼 睑板腺功能障碍 结膜松弛症 |
| 收稿时间： | 2020-08-06 |
Research progress of cell senescence in ocular surface diseases |
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| Liu Jiang,Wen Hang,Xiang Minhong.Research progress of cell senescence in ocular surface diseases[J].International Review of Opthalmology,2021,45(1):71-75. |
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| Authors: | Liu Jiang Wen Hang Xiang Minhong |
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| Institution: | Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China |
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| Abstract: | Cell senescence refers to the attenuation of cell physiological functions, including phenomena such as decreased proliferation capacity, cell cycle arrest, cell apoptosis, and increased expression of senescence\|related genes. In recent years, with people's further understanding of aging and the continuous supplement and upgrade of cell aging detection methods, new ideas and new methods have been provided for clinical treatment of aging\|related diseases. At present, many ocular surface diseases are found to be related to aging, such as dry eye, meibomian gland dysfunction, conjunctiochalasis, Fuchs corneal endothelial dystrophy, pterygium and pinguecula. It suggests that the ocular surface diseases can be further understood, diagnosed and treated from the perspective of cell senescence. |
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| Keywords: | cell senescence ocular surface diseases dry eye meibomian gland dysfunction conjunctivochalasis |
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