光损伤视网膜细胞的机制研究

人类通过阳光和人工光源的照明实现“看得见”的基本功能.外界光穿过眼前部透明屈光介质后进入视网膜,通过视循环完成光电转化,将光信号转化为神经信号传递至大脑视觉中枢.随着平均寿命的延长和人工光源的增加,光辐射对视网膜的损伤受到越来越多的关注,但其机制仍未完全阐明.本文就视网膜光损伤机制的最新研究进展进行综述,讨论了光损伤视...

Mechanisms of light damage to retinal cells

“Seeing” is the basic function of the human eye and the light is everywhere for the eyes. The light passes through the cornea and lens to the retina. After absorbing the photons, the outer segment of the photoreceptors completes the photoelectric transformation through the visual cycle, and transmitting the external visual information to the visual center in the brain. With the increased longevity and artificial light sources, light radiation has an increasing impact on our retinal health, but the mechanisms are not yet clear. We reviewed the studies on light\|induced damage in the retina and discussed the pathological changes such as increased reactive oxygen species, lipofuscin accumulation, and inflammatory activation in the retina: photoreceptor cells, retinal pigment epithelial cells, and glial cells after light damage. Knowledge of mechanisms of light damage can improve our understanding of some disease processes that may be associated with light damage, and aid in the development of new therapies.