DOUBLE-BLIND PROSPECTIVE RANDOMIZED STUDY COMPARING POLYETHYLENE GLYCOL
TO LACTULOSE FOR BOWEL PREPARATION IN COLONOSCOPY |
| |
Authors: | Aline Moraes MENACHO Adriano REIMANN Lie Mara HIRATA Caroline GANZERELLA Flavio Heuta IVANO Ricardo SUGISAWA |
| |
Institution: | From the Serviço de Endoscopia do Hospital de Caridade Irmandade Santa Casa de Misericórdia de Curitiba, Curitiba, PR, Brazil |
| |
Abstract: | BackgroundColonoscopy is the most frequent exam used to evaluate colonic mucosa, allowing
the diagnosis and treatment of many diseases. The appropriate bowel preparation is
indispensable for the realization of colonoscopy. Therefore, it is necessary the
use of laxative medications, preferentially by oral administration.AimTo compare two medications used in bowel preparation in adult patients going to
ambulatory colonoscopy and to analyze the patients'' profile.MethodsA double-blind prospective study with 200 patients, randomized in two groups: one
that received polyethilene glycol and another that received lactulose. The
patients answered to questionnaires to data compilation, as tolerance, symptoms
and complications related to preparation. Besides, it was also evaluated the
prepare efficacy related to the presence of fecal residue.ResultsIntestinal habit alterations and abdominal pain were the main reasons to realize
the exams and hypertension was the most prevalent comorbidity. Ten percent of the
ones who received lactulose didn''t get to finish the preparation and 50%
considered the taste "bad, but tolerable". The most common subjective symptom
after the medication was nausea, especially after lactulose. During the exam, most
of the patients who used lactulose had a "light discomfort" and the ones who used
polyethilene glycol considered the discomfort as "tolerable". The quality of the
preparation was good in 75%, undependable of the medication that was used.ConclusionPolyethilene glycol was more tolerable when compared to lactulose, without
difference on the quality of the preparation. |
| |
Keywords: | Colonoscopy Bowel preparation Polietilenoglicol Lactulose |
|
|