| 色素性青光眼的发病机制 |
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| 引用本文： | 蒲丽萍,卿国平.色素性青光眼的发病机制[J].国际眼科纵览,2021,45(3):183-187. |
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| 作者姓名： | 蒲丽萍 卿国平 |
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| 作者单位： | 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室 100730 |
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| 基金项目： | 国家自然科学基金（81970795） |
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| 摘 要： | 色素性青光眼是一类发病机制相对"单纯"的继发性开角型青光眼,眼压升高的主要原因在于大量色素颗粒沉积于小梁网并导致房水流出阻力增加.色素颗粒除了机械性堵塞小梁网间隙,还可导致吞噬色素颗粒超负荷的小梁细胞死亡、裂解,小梁柱暴露并相互融合,小梁网间隙变窄甚至消失.此外,葡萄膜巩膜途径房水动力学改变,复杂的分子遗传以及免疫机制...
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| 关 键 词： | 色素播散综合征 色素性青光眼 眼压 |
| 收稿时间： | 2021-02-07 |
The pathogenesis of pigmentary glaucoma |
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| Pu Liping,Qing Guoping.The pathogenesis of pigmentary glaucoma[J].International Review of Opthalmology,2021,45(3):183-187. |
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| Authors: | Pu Liping Qing Guoping |
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| Institution: | Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China |
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| Abstract: | Pigmentary glaucoma is a kind of secondary open-angle glaucoma with relatively simple pathogenesis. The main reason for elevated intraocular pressure is increased aqueous outflow resistance owing to an accumulation of pigment granules in the trabecular meshwork. These pigment granules can not only cause mechanical obstruction of the intertrabecular spaces, but also lead to the loss of trabecular cells which had overload phagocytized pigment granules, the fusion of trabecular lamellae with collapse of intertrabecular spaces, and the obliteration of the canal. In recent studies, the aqueous humor dynamic changes in the uveosceleral outflow pathway, complex molecular genetics and immune mechanism might be involved in the pathogenesis of pigmentary glaucoma. (Int Rev Ophthalmol, 2021, 45: 183-187) |
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