基于BiblioShiny的先天性白内障可视化文献计量分析（2011─2020年）

目的：基于BiblioShiny程序分析2011 ─2020 年全球先天性白内障的研究现状与发展趋势，为进一步的研究提供参考信息。方法：文献计量分析方法。运用基于R语言的科学文献计量BiblioShiny程序，对2011 ─2020 年Web of ScienceTM核心合集数据库（WoSCC）收录的关于先天性白内障的相关文献，从期刊、国家与作者分布、共词分析、共被引分析、合作网络等深入分析全球先天性白内障的研究知识基础和研究前沿热点。结果：①共纳入1 492篇研究文献，以中国和美国发文量最多。②《MolecularVision》杂志的出版物发表量排名榜首，刊文74 篇，其次是《PLoS One》，刊文66 篇，二者均为美国期刊。③发文量第1位的是来自加利福尼亚州帕罗奥多市斯坦福大学医学院眼科的Lambert SR博士。④先天性白内障领域的知识基础是先天性白内障和基因突变，目前的学术研究热点是基因表达主题。⑤研究方向可以分为3大集群：第1集群为先天性白内障的发病率、危险因素和手术治疗等；第2集群的研究内容主要是分子遗传、基因突变和蛋白质功能改变等；第3集群的研究内容主要集中在晶状体蛋白的结构、稳定性和功能等。结论：2011 ─2020 年先天性白内障研究领域中，中国和美国为发文量最多的国家，但是美国在国家间、机构间的合作网络均远大于中国，提示中国可提高国家、机构间的合作率。目前先天性白内障主流研究方向可分为临床治疗、基因层面和蛋白质层面。

A Visual Bibliometric Analysis of Congenital Cataract-Based on BiblioShiny (2011-2020)

Objective: To analyze the current status and developmental trends of global congenital cataract researchfrom 2011 to 2020 using the bibliometric method based on the Web of ScienceTM core collection databaseand to provide reference information for further research. Methods: This article uses the BiblioShinyprogram of scientific bibliometrics based on the R language to analyze the congenital cataract researchliterature included in the Web of Science Core Collection (WoSCC) from 2011 to 2020, based on journals,country and author distribution, keyword co-word analysis, co-citation analysis, collaboration network, etc.The research knowledge base and research frontier hotspots of global congenital cataract were analyzed.Results: ①A total of 1 492 studies were included. China and the United States had the largest number ofpublications and were in the leading position. ②The publication volume of 《Molecular Vision》 journalranked first, with 74 published articles, followed by 《PLoS One》 with 66 published articles. Both areAmerican journals. ③Dr. Scott R. Lambert from the Department of Ophthalmology, Stanford UniversitySchool of Medicine, Palo Alto, California had the most publications. ④The knowledge base in the fieldof congenital cataracts were congenital cataracts and gene mutations, and the current academic researchhotspot was the topic of gene expression. ⑤The direction of research can be divided into three majorclusters: The first cluster is the incidence of congenital cataract, risk factors, surgical treatment, etc. Thesecond cluster is mainly molecular genetics, gene mutations, etc. The third cluster is mainly focused on thestructure, stability and function of lens protein. Conclusions: In the field of congenital cataracts from 2011to 2020, China and the United States are the countries with the largest number of publications. However,the collaboration network between countries and institutions in the United States is much larger than thatof China. The current mainstream research directions can be divided into clinical treatment and gene andprotein levels.