早产儿视网膜病变激光光凝术后角膜地形图状况

目的：:观察早产儿视网膜病变（ROP）激光光凝术后儿童角膜地形图的改变。方法：:病例对照研究。收集2015年9月至2018年4月于深圳市眼科医院行激光光凝术后的ROP儿童25例（50眼）为ROP组，同时收集年龄匹配的足月儿童23例（46眼）为对照组。2组儿童均行最佳矫正视力（BCVA）检查，统计分析时转换为LogMAR...

Corneal Topography of Children after Laser Photocoagulation for Retinopathy of Prematurity

Objective: To observe the changes in corneal topography of children after laser photocoagulation for retinopathy of prematurity (ROP). Methods: In this case-control study, 25 children (50 eyes) with ROP who received laser photocoagulation for ROP in Shenzhen Eye Hospital from September 2015 to April 2018 were selected after laser photocoagulation were the ROP group, and 23 full-term, age-matched children (46 eyes) were selected for the control group. The two groups of children underwent best corrected visual acuity (BCVA) testing, recalculated into logMAR visual acuity. For each group of children, the Sirius anterior eye assay system measured: Maximum value (K1), minimum value (K2), and average corneal curvature (Avg) of different diameter ranges on the anterior and posterior surfaces of the cornea; steep radius (rs), flat radius (rf), and aspheric parameter (e) of different diameter ranges on the anterior and posterior surfaces of the cornea. A t-test, was used for differences between the quantitative data between the groups. Results: ①The BCVAs of the ROP group and control group were 0.24±0.25 and 0.07±0.10, respectively, and the difference between the two groups was statistically significant (t=3.20, P=0.003). ②The corneal anterior and posterior surface curvature and corneal refractive power of different diameter ranges in the ROP group were greater than that of the control group, and the difference was statistically significant [K1 (anterior corneal surfaces 3 mm, 5 mm, 7 mm, posterior corneal surfaces 3 mm, 5 mm, 7 mm): t=3.139, 3.050, 2.710, -4.216, -3.821, -2.474; K2 (anterior corneal surfaces 3 mm, 5 mm, 7 mm, posterior corneal surfaces 3 mm, 5 mm, 7 mm): t=2.816, 2.688, 2.286, -4.252, -3.883, -3.178; Avg (anterior corneal surfacse 3 mm, 5 mm, 7 mm, posterior corneal surfaces 3 mm, 5 mm, 7 mm): t=3.190, 3.041, 2.649, -4.848, -4.271, -3.121, all P<0.05]. ③The corneal morphology of the ROP group was different than that of the control group, and the difference was statistically significant [rf (anterior corneal surfaces 6 mm, 8 mm, posterior corneal surfaces 6 mm, 8 mm): t=3.395, 3.354, -4.427, -4.613; rs (anterior corneal surfaces 6 mm, 8 mm, posterior corneal surfaces 6 mm, 8 mm): t=2.928, 2.807, -4.055, -4.175, e (anterior corneal surfaces 6 mm, 8 mm, posterior corneal surfaces 6 mm, 8 mm): t=3.437, 3.991, 2.268, 4.355, all P<0.05]. Conclusions: The Sirius anterior eye assay system has a significant advantage in our study of total corneal development. We found that after laser photocoagulation, ROP children have a higher refractive power in different ranges of the anterior and posterior surfaces of the cornea, and a lower BCVA. They are more likely to have refractive errors and other changes in visual function during visual development compared with full-term children.