我国早产儿视网膜病发病率的Meta分析

目的: 采用Meta分析方法评价中国早产儿视网膜病的发病情况。方法: 计算机检索PubMed、Web of Science、Cochrane Library、Embase、CBM、CNKI、Wanfang Data和VIP数据库中关于中国早产儿视网膜病发病率的文献,检索时间为从建库到2020年12月。由2名研究者筛选文献、提取资料并评价纳入文献的偏倚风险,采用Stata12.0软件对结果进行Meta分析。结果: 共纳入28篇文献,包含75 572例患者。Meta分析结果显示,中国早产儿视网膜病发病率为12.6%（95%CI：11.1%~14.1%）,其中男性为16%（95%CI：14%~18%）,女性为16%（95%CI：14%~19%）。按胎龄分组：≤30周为38%（95%CI：25%~51%）,30~32周为21%（95%CI：13%~29%）,≥32周为12%（95%CI：3%~20%）。按体质量分组：≤1.5 kg为32%（95%CI：28%~35%）,1.5~2.0 kg为11%（95%CI：9%~14%）,≥2.0 kg为5%（95%CI：4%~7%）。按地区分组：南方为13%（95%CI：12%~14%）,北方为13%（95%CI：12%~15%）。亚组分析显示,胎龄越小发病率越高,且发病率随胎龄增长而降低。南方地区与北方地区发病率一致。结论: 我国早产儿视网膜病的发病率为12.6%,但不同胎龄、体质量发病率存在差异。

Prevalence of Retinopathy of Prematurity in China: A Meta-Analysis

Objective: To evaluate the prevalence of retinopathy of prematurity (ROP) in China by a meta-analysis. Methods: PubMed, Web of Science, Cochrane Library, Embase, CBM, CNKI, Wanfang Data and VIP databases were searched for cross-section studies on retinal disease of preterm infants in China from the date of establishment to December 2020. Two researchers screened the literature, extracted the data, and evaluated the risk of bias in the included studies. The meta-analysis was performed by using Stata12.0 software. Results: A total of 28 studies involving 75 572 patients were included. The results of meta-analysis showed that the prevalence of ROP in Chinese premature infant was 12.6% (95%CI: 11.1% to 14.1%), of which 16% (95%CI: 14% to 18%) for male and 16% (95%CI: 14% to 19%) for female. Grouped by gestational age, 38% (95%CI: 25% to 51%) for ≤30 weeks, 21% (95%CI: 13% to 29%) for 30-32 weeks, and 12% (95%CI: 3% to 20%) for ≥32 weeks. Grouped by body weight, ≤1.5 kg is 32% (95%CI: 28% to 35%), 1.5-2.0 kg is 11% (95%CI: 9% to 14%), ≥2.0 kg is 5% (95%CI: 4% to 7%). Grouped by region, 13% (95%CI: 12% to 14%) in the south, and 13% (95%CI: 12% to 15%) in the north. Subgroup analysis showed that the prevalence was higher in younger age, and the prevalence decreased with the increase of gestational age. The prevalence was the same in the south and the north. Conclusions: The prevalence of ROP in China is 12.6%. There are differences in this rate among preterm infants of different gestational age and body weight.