天然产物通过调节活性氧水平防治肿瘤的研究进展

活性氧(Reactive oxygen species,ROS)广泛存在于生物体内.正常情况下的ROS水平保持较低浓度以维持正常细胞功能.研究发现,正常组织中ROS水平的异常升高将诱导的肿瘤发生发展;而进一步提高浓度的ROS则具有诱导肿瘤细胞凋亡等抗肿瘤作用.ROS已成为肿瘤防治研究的重要靶点之一.天然产物广泛存在于自...

Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level

Reactive oxygen species (ROS) is widespread in living organisms. Under normal conditions, ROS remains at low concentrations to maintain normal cell function. Studies have found that the abnormal elevation of ROS levels in normal tissues is an important mechanism underlying the tumorigenesis. However, high concentrations of ROS also have toxic, genotoxic, and even apoptotic effects on tumor cells. ROS has become one of the important targets for cancer prevention and treatment. Natural products widely exist in nature and have a wide range of pharmacological activities, which can affect the function of ROS. In the present study, we reviewed the research progress of natural products in tumor prevention and treatment by regulating ROS level in recent years.