90Sr敷贴和CO2激光治疗尖锐湿疣临床疗效的Meta分析

目的 分析评价90Sr敷贴和CO₂激光两种疗法对尖锐湿疣（CA）的治疗效果。 方法 检索2000至2017年PubMed、中国知网、万方、维普等文献数据库收录的使用90Sr敷贴和CO₂激光治疗CA患者的相关中英文文献，按照纳入和排除标准收集符合条件的文献，采用Jadad量表对纳入的文献进行质量评价，其标准采用0~5分记分法，≤2分为低质量证据，≥3分为高质量证据。计算纳入文献的合并比值比（OR）和95%可信区间（CI）。采用χ2检验进行文献异质性检验，采用Begg法和漏斗图法检验纳入文章的发表偏倚。 结果 共纳入3篇2003至2011年发表的相关文献，均为中文文献，合计228例患者。3篇文献的Jadad评分分别为4、4、3分。纳入的文献之间不存在异质性（治愈率:I2=0、P=0.685；复发率:I2=0、P=0.954）。Begg法（Z=0.045，P>0.05）和漏斗图法检验结果显示，纳入的文献间不存在发表偏倚。在治愈率方面，与CO₂激光治疗相比，90Sr敷贴治疗对CA治愈率影响的合并OR为1.05，95%CI为0.72~1.54；在复发率方面，与CO₂激光治疗相比，90Sr敷贴治疗对CA复发率影响的合并OR为0.06，95%CI为0.02~0.24。 结论 90Sr敷贴与CO₂激光治疗CA的疗效相似，但经90Sr敷贴治疗后的复发率更低。

Therapeutic efficacy of condyloma acuminata by using 90Sr applicator and CO2 laser: a meta-analysis

Objective To evaluate the therapeutic effects of 90Sr applicator and CO₂ laser treatment on condyloma acuminata (CA). Methods Searched PubMed, China national knowledge infrastructure, Wanfang, cqvip, and other literature databases for Chinese and English articles related to the use of 90Sr applicator and CO₂ laser treatment for patients with CA from 2000 to 2017. Eligible studies were collected according to the inclusion and exclusion criteria. The Jadad scal was used to evaluate the quality of the included articles. The standard used a 0–5 point scoring method. A score of ≤2 was regarded as low-quality evidence, and a score of ≥3 was regarded as high-quality evidence. Meta-analysis was performed on count data by using Stata 12.0 software to calculate pooled odds ratio (OR) and 95% confidence interval (CI). χ2 test was used to assess the heterogeneity of the articles, and Begg's test and funnel plot method were used to detect the publication bias of the included articles. Results This work included three eligible Chinese studies (a total of 228 patients) published from 2003 to 2011. The Jadad scores of the three articles were 4, 4, and 3 points, respectively. Heterogeneity was not detected among the included articles (cure rate: I2=0, P=0.685; recurrence rate: I2=0, P=0.954). The Begg's test (Z=0.045, P>0.05) and the funnel plot method showed no publication bias among the included articles. The merge OR of 90Sr applicator on the cure rate of CA was 1.05, with 95%CI of 0.72–1.54. The merge OR of 90Sr applicator on the recurrence rate of CA was 0.06, with 95%CI of 0.02–0.24. Conclusion 90Sr applicator is an effective clinical treatment that has similar therapeutic effects and lower recurrence rate than CO₂ laser.