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18F-FDG和 68Ga-DOTA-SSA双示踪剂PET/CT在神经内分泌肿瘤中的临床应用
引用本文:赵润泽,张一帆. 18F-FDG和 68Ga-DOTA-SSA双示踪剂PET/CT在神经内分泌肿瘤中的临床应用[J]. 国际放射医学核医学杂志, 2021, 45(9): 585-590. DOI: 10.3760/cma.j.cn121381-202008043-00091
作者姓名:赵润泽  张一帆
作者单位:上海交通大学医学院附属瑞金医院核医学科 200025
摘    要:与常规CT和MRI影像学检查相比,68Ga-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)-生长抑素类似物(SSA)PET/CT在神经内分泌肿瘤(NEN)的诊断中具有较高的灵敏度和特异度,同时,在疗效评价和预后评估等方面也有重要的指导价值。18F-氟脱氧葡萄糖(FDG)PET/CT虽然在NEN的诊断中未被常规推荐,但其在良恶性肿瘤的鉴别诊断和预后评估中可提供额外的信息。笔者就近年来18F-FDG和68Ga-DOTA-SSA双示踪剂PET/CT在NEN中的临床应用进行综述。

关 键 词:神经内分泌瘤  正电子发射断层显像术  体层摄影术,X线计算机  氟脱氧葡萄糖F18  镓-68  生长抑素类似物
收稿时间:2020-08-25

Clinical application of 18F-FDG and 68Ga-DOTA-SSA dual-tracer PET/CT in neuroendocrine neoplasms
Runze Zhao,Yifan Zhang. Clinical application of 18F-FDG and 68Ga-DOTA-SSA dual-tracer PET/CT in neuroendocrine neoplasms[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2021, 45(9): 585-590. DOI: 10.3760/cma.j.cn121381-202008043-00091
Authors:Runze Zhao  Yifan Zhang
Affiliation:Department of Nuclear Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract:Compared with conventional CT and MRI imaging examinations, 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-somatostatin analog (SSA) PET/CT has higher sensitivity and specificity in the diagnosis of neuroendocrine neoplasm (NEN), and it also has important guiding value in the evaluation of curative effect and prognosis. Although not routinely recommended in the diagnosis of NEN, 18F-fluorodeoxyglucose (FDG) PET/CT can provide complementary information in the differential diagnosis of benign and malignant tumors and the evaluation of prognosis. An overview of the clinical application of 18F-FDG and 68Ga-DOTA-SSA dual-tracer PET/CT in NEN is presented.
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