| 68Ga-FAPI PET/CT在恶性肿瘤中的临床应用 |
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| 引用本文： | 倪妙琪,吴爽,金晨涛,田梅. 68Ga-FAPI PET/CT在恶性肿瘤中的临床应用[J]. 国际放射医学核医学杂志, 2021, 45(5): 307-312. DOI: 10.3760/cma.j.cn121381-202102029-00046 |
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| 作者姓名： | 倪妙琪 吴爽 金晨涛 田梅 |
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| 作者单位： | 浙江大学医学院附属第二医院核医学科，杭州 310009 |
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| 摘 要： | 成纤维细胞激活蛋白（FAP）作为肿瘤相关成纤维细胞（CAFs）的分子标志物之一，在激活的CAFs中高度特异性表达。FAP具有促进肿瘤侵袭、转移和免疫逃逸的作用，可作为恶性肿瘤诊疗的重要靶点。镓-68标记的FAP抑制剂（ 68Ga-FAPI）是基于FAP合成的小分子探针，经PET/CT显像可实现FAP在体内的可...
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| 关 键 词： | 正电子发射断层显像术 体层摄影术，X线计算机 放射性核素显像 成纤维细胞激活蛋白抑制剂 |
| 收稿时间： | 2021-02-25 |
Clinical application of 68Ga-FAPI PET/CT in malignant tumors |
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| Miaoqi Ni,Shuang Wu,Chentao Jin,Mei Tian. Clinical application of 68Ga-FAPI PET/CT in malignant tumors[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2021, 45(5): 307-312. DOI: 10.3760/cma.j.cn121381-202102029-00046 |
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| Authors: | Miaoqi Ni Shuang Wu Chentao Jin Mei Tian |
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| Affiliation: | Department of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China |
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| Abstract: | Fibroblast activation protein (FAP), as one of the molecular markers of cancer-associated fibroblasts (CAFs), is highly specifically expressed in activated CAFs. FAP can be used as a theranostic target for malignant tumors since it can promote tumor invasion, metastasis and immune escape. Gallium-68-labeled FAP inhibitor (68Ga-FAPI) is a small molecular probe synthesized based on FAP, which can be visualized in vivo by PET/CT imaging. At present, 68Ga-FAPI PET/CT has been successfully used in the diagnosis and staging of glioma, esophageal cancer, hepatocellular carcinoma, pancreatic ductal adenocarcinoma and other malignant tumors. This paper reviews the clinical application of 68Ga-FAPI PET/CT in malignant tumors. |
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