控烟是预防肺癌的主要措施——记太原市肺癌病例对照流行病学调查

背景 与目的:山西省太原市空气污染常较为严重.了解各种类型肺癌的危险因素,以采取有效的预防措施.方法:2005年3月—2007年9月,山西省太原市396例肺癌新发病例和465名健康对照者纳入本研究.利用太原市肿瘤医院病理学检查确诊的肺癌病例,配以人群为基础、随机选择的对照,进行病例对照询问调查和环境监测.分析时注意排除...

The control of lung cancer relating to quitting active smoking and secondary smoking: a case-control study of lung cancer in Taiyuan

Background and purpose: Taiyuan City of Shanxi Province is one of the cities in China with serious air pollution. This study aimed to understand the risk factors of various types of lung cancer in order to take effective preventive measures. Methods: From March 2005 to September 2007, 396 lung cancer patients from Taiyuan Cancer Hospital and 465 healthy control persons were included in this study. The lung cancer cases diagnosed by pathology in Taiyuan Cancer Hospital were matched randomly selected population-based controls to carry out case-control investigation and environmental monitoring. During the analysis, the risk factors other than case-control risk factors were excluded and balanced, and the trend test was carried out at the same time; multivariate unconditional logistic regression analysis was used to analyze various risk factors, including odds ratio (OR) and 95% confidence interval (95% CI). Results: The results showed smoking was closely related to lung cancer. The risk of lung cancer in smokers was significantly higher than that in non-smokers (OR=3.75, 95% CI: 2.39-5.89), especially in lung squamous cell carcinoma and small cell lung cancer (OR=5.01 and 5.06). There was a significant dose-effect relationship between lung cancer and smoking amount, smoking years and smoking depth. Passive smoking, or long-term use of solid fuel in kitchen for cooking and heating also played an important role in the occurrence and development of lung cancer. The research of PM2.5 has just begun, andno significant correlation between indoor particulate matter pollution and lung cancer has been found. Conclusion: Smoking is still an important risk factor for lung cancer in Taiyuan City. Passive smoking and solid fuel cooking should not be ignored.