| LncRNA调控肿瘤细胞辐射敏感性作用的研究进展 |
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| 引用本文： | 赵舒雅,李航,樊赛军.LncRNA调控肿瘤细胞辐射敏感性作用的研究进展[J].国际放射医学核医学杂志,2021,45(11):701-709. |
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| 作者姓名： | 赵舒雅 李航 樊赛军 |
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| 作者单位： | 中国医学科学院北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室 300192 |
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| 摘 要： | 放疗是治疗恶性肿瘤的主要方法之一，但放疗的效果在不同类型的肿瘤及个体间都存在差异，解决这一问题的重要手段之一是提高肿瘤的放射敏感性。长链非编码RNA（lncRNA）通过多种机制影响肿瘤细胞的放射敏感性，未来有望成为放疗的辅助治疗靶点。笔者综述了lncRNA参与肿瘤放疗抵抗过程的作用模式及其相关的分子机制。
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| 关 键 词： | 辐射耐受性 放射疗法 RNA，长链非编码 |
| 收稿时间： | 2021-01-18 |
Research progress in the role of lncRNA in regulating radiationsensitivity of cancer cells |
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| Shuya Zhao,Hang Li,Saijun Fan.Research progress in the role of lncRNA in regulating radiationsensitivity of cancer cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2021,45(11):701-709. |
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| Authors: | Shuya Zhao Hang Li Saijun Fan |
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| Institution: | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China |
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| Abstract: | Radiotherapy is one of the main modalities of cancer treatment, but the benefits from radiotherapy varies among different types of tumors and individuals. One of the important means to solve this problem is to improve the radiosensitivity of tumor tissues. Recent studies have shown that long non-coding RNA (lncRNA) influences the radiosensitivity of tumor cells through multiple mechanisms, and is expected to be an adjuvant therapeutic target for radiotherapy in the near future. In this paper, the authors review the action of lncRNA involved in the process of tumor radiotherapy resistance and its related molecular mechanisms. |
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