Metastasis of carcinoma ex pleomorphic adenoma to the brain without previous metastasis to the lungs or bones: a case report |
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| Institution: | 1. Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Applied Life Science, Graduate Institute of Biomedical and Health Science, Hiroshima University;2. Oral and Maxillofacial Surgery, Hiroshima University Hospital;1. William Harvey Hospital, EKHUFT, Ashford, KENT TN24 0LZ;2. Dept. of Informatics, King''s College London, London;1. University of Southampton;2. Royal Surrey County Hospital;3. University Hospital Southampton;1. Department of Oral and Maxillofacial Surgery, Manchester University NHS Foundation Trust, Manchester Royal Infirmary, Manchester, M13 9WL;2. University of Birmingham, College of Medical and Dental Sciences, Birmingham, B15 2TT;3. Department of General Surgery, New Cross Hospital, Wolverhampton, WV10 0QP;4. Department of Oral and Maxillofacial Surgery, University Hospital Birmingham, B15 2TH;1. Oral and Maxillofacial Surgery, Leeds Teaching Hospitals NHS Trust, LS2 9LU, Leeds;2. Oral and Maxillofacial Surgery, City Hospitals Sunderland NHS Foundation Trust, Sunderland;3. BAOMS Quality Outcome Metrics Project Manager, British Association of Oral and Maxillofacial Surgeons, Royal College of Surgeons of England, 35/43 Lincoln’s Inn Fields, WC2A 3PE, London;4. Oral and Maxillofacial Surgery, Aintree University Hospitals NHS Foundation Trust, Lower Lane, Fazakerly, L9 7AL, Liverpool;5. Oral and Maxillofacial Surgery, Central Manchester University Hospitals NHS Foundation Trust, Manchester;6. Maxillofacial Department, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, B15 2TH, Birmingham;7. Oral and Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead;8. Oral and Maxillofacial Surgery, Guy’s and St Thomas’ NHS Foundation Trust, London;9. Maxillofacial Unit, Queen Alexandra Hospital, PO6 3LY, Portsmouth;10. National Maxillofacial Unit, St. James’s Hospital, James’s Street, Dublin 8, Ireland;11. Oral and Maxillofacial Surgery, NHS Greater Glasgow and Clyde, Glasgow;1. National Maxillofacial Unit, St. James’s Hospital, James’s Street, Dublin 8, Ireland;2. Surgery, Anaesthesia and Critical Care Directorate, St. James’s Hospital, James’s Street, Dublin 8, Ireland;3. Department of Anaesthesia, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, Ireland |
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| Abstract: | Carcinoma ex pleomorphic adenoma is a rare type of cancer of the salivary gland that involves the malignant transformation of a primary or recurrent pleomorphic adenoma, which often metastasises to the lungs or bones, or both. To the best of our knowledge, however, nobody has reported a distant metastasis of this lesion to the brain without such previous metastasis. We report a case in a 64-year-old man. |
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| Keywords: | Carcinoma ex pleomorphic adenoma Cetuximab Bioradiotherapy Brain metastasis Blood-brain barrier |
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