地夸磷索钠滴眼液对中重度干眼患者眼表状况和视觉质量的影响

目的：:评价3%地夸磷索钠滴眼液对中重度干眼患者眼表状况和视觉质量的改善效果。方法：:前瞻性临床研究。收集2019年9月至2020年8月在武汉大学人民医院眼科门诊就诊的中重度干眼患者78例（78眼），将其按随机数字表法随机分为人工泪液组38例（38眼）和地夸磷索钠滴眼液组40例（40眼），人工泪液组使用人工泪液点眼3次...

Effect of Diquafosol Sodium on the Ocular Surface and the Visual Quality of Patients with Moderate to Severe Dry Eyes

Objective: To evaluate changes in the ocular surface status and the visual quality in patients with moderate to severe dry eyes before and after treatment with 3% diquafosol sodium eye drops. Methods: In this prospective clinical study, a total of 78 patients (78 eyes) with moderate to severe dry eye were included from the ophthalmic outpatient department of Renmin Hospital of Wuhan University from September 2019 to August 2020. Patients were randomly divided into two groups based on the criteria. In the artificial tear group, 38 patients (38 eyes) were treated with artificial tear drops for 3 s/d; in the diquafosol sodium group, 40 patients (40 eyes) were treated with diquafosol sodium for 6 s/d and artificial tear for 3 s/d. The therapeutic effect was observed 1 month after treatment. The data were analyzed by sample t test,Chi-square and Spearman correlation. Results: After 1 month of treatment, the two groups of patients had improved, and the effect in the diquafosol sodium group was better than that in the artificial tears group for break-up time (BUT), tear meniscus height, Schirmer Ⅰ test, corneal fluorescein staining (FL) and the tear film objective scatter index (TF-OSI) (t=2.613, P=0.029; t=8.498, P=0.001; t=4.082, P=0.015; t=15.06, P<0.001; t=5.021, P=0.007). TF-OSI was negatively correlated with BUT and Modulation transfer function cut off before and after use in the two groups (r=-0.298, P=0.045; r=-0.478, P=0.033; r=-0.478, P=0.004; r=-0.399, P=0.006), and TF-OSI was positively correlated with the dry eye questionnaire score (OSDI) and FL in the diquafosol sodium group (r=0.479, P=0.035; r=0.254, P=0.027). Conclusions: Diquafosol sodium combined with artificial tears can effectively improve the clinical symptoms and signs of moderate to severe dry eyes, and can effectively improve the visual quality of patients. This improvement is better than treatment with artificial tears alone.