| 代谢组学技术在糖尿病视网膜病变中的研究进展 |
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| 引用本文： | 周子曦,郑政,郑敏明.代谢组学技术在糖尿病视网膜病变中的研究进展[J].国际眼科纵览,2021,45(1):44-50. |
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| 作者姓名： | 周子曦 郑政 郑敏明 |
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| 作者单位： | 重庆医科大学附属第二医院眼科 400010 |
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| 基金项目： | 重庆市自然科学基金（cstc2019jcyj-msxmX028）；重庆市卫生计生委项目（ZY201602085） |
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| 摘 要： | 代谢组学是研究生物体系受外部刺激或扰动后所产生的内源性代谢物整体及其变化的新兴学科.糖尿病视网膜病变(diabetic retinopathy,DR)代谢组学共同特征表现在三大代谢途径及抗坏血酸途径的显著富集,其中d-葡萄糖、2-脱氧核糖酸、天冬酰胺、谷氨酰胺、精氨酸、瓜氨酸、脯氨酸及肉碱含量升高,抗坏血酸、天冬氨酸及...
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| 关 键 词： | 糖尿病视网膜病变 代谢组学 生物标志物 代谢途径 |
| 收稿时间： | 2020-09-09 |
Progress of metabolomics technology in diabetic retinopathy |
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| Zhou Zixi,Zheng Zheng,Zheng Minming.Progress of metabolomics technology in diabetic retinopathy[J].International Review of Opthalmology,2021,45(1):44-50. |
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| Authors: | Zhou Zixi Zheng Zheng Zheng Minming |
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| Institution: | Department of Ophthamology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China |
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| Abstract: | Metabolomics is an emerging discipline that studies the whole and changes of endogenous metabolites produced by biological systems after external stimuli or disturbances. The common feature of diabetic retinopathy (DR) metabolomics is the significant enrichment of the three major metabolic pathways and the ascorbic acid pathway, including d\|glucose, 2\|deoxyribonate, asparagine, glutamine, arginine, citrulline, and proline and carnitine content increased, ascorbic acid，aspartic acid and glutamic acid content decreased. |
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| Keywords: | diabetic retinopathy metabolomics biomarkers metabolic pathway |
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