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老年性痴呆患者尿中AD7c-NTP含量的研究
引用本文:闫鹏,王蓉,杜怡峰,沈伦乾.老年性痴呆患者尿中AD7c-NTP含量的研究[J].山东大学学报(医学版),2009,47(6):106.
作者姓名:闫鹏  王蓉  杜怡峰  沈伦乾
作者单位:闫鹏,杜怡峰,沈伦乾,YAN Peng,DU Yi-feng,SHEN Lun-qian(山东大学附属省立医院神经内科,济南,250021);王蓉,WANG Rong(首都医科大学宣武医院神经内科,北京脑老化研究实验室,北京,100053)  
摘    要:目的 探讨尿中阿尔茨海默病相关的神经丝蛋白(AD7c-NTP)含量在老年性痴呆(AD)诊断中的价值。 方法  采用酶联免疫吸附测定法(ELISA),检测AD组(分轻、中、重3组)65例、血管性痴呆组(VaD组) 60例、智能正常老年对照组120例尿液中AD7c-NTP含量,所有数据均经SPSS 13.0软件进行统计学处理。 结果AD组、VaD组与智能正常老年对照组尿液中AD7c-NTP含量分别为(2.50±0.45)、(1.19±0.68) 、(1.21±0.74) ng/mL,AD组明显高于另外两组,而VaD组与智能正常老年对照组差异无统计学意义(P>0.05); AD组内患者尿液AD7c-NTP含量与其痴呆程度呈正相关。 结论 尿液中AD7c-NTP含量在AD诊断和病情评估中有重要的临床参考价值。

关 键 词:阿尔茨海默病  痴呆  血管性  阿尔茨海默病相关的神经丝蛋白  酶联免疫吸附测定  尿
收稿时间:2009-01-07

AD7c-NTP level in urine of patients with Alzheimer′s disease
YAN Peng,WANG Rong,DU Yi-Feng,SHEN Lun-Qian.AD7c-NTP level in urine of patients with Alzheimer′s disease[J].Journal of Shandong University:Health Sciences,2009,47(6):106.
Authors:YAN Peng  WANG Rong  DU Yi-Feng  SHEN Lun-Qian
Institution:1.Department of Neurology;Provincial Hospital Affiliated to Shandong University;Jinan 250021;China;2.Beijing Brain Aging Research Institute;Xuan Wu Hospital;Capital University of Medical Sciences;Beijing 100053;China
Abstract:Objective To explore the value of urine AD7c-NTP assay in clinical diagnosis of Alzheimer's disease (AD). Methods  The urine AD7c-NTP level was determined using Enzyme-linked immunosorbent assay in 245 elderly people, who were divided into three groups: the  AD group(n=65),the  vascular dementia group (VaD, n=60) and the normal mental state group (n=120). Statistical analysis was performed using SPSS 13.0. Results  The urine AD7c NTP content of the three groups were (2.50±0.45)ng/ml, (1.19±0.68)ng/ml and (1.21±0.74)ng/ml. Compared with the normal mental state group and the VaD group, AD group had a significant increase of the urine AD7c-NTP level, which was positively correlated with the severity of the disease. No significant difference was found between the VaD group and the normal mental state group. Conclusion  Urine AD7c-NTP level, probably a biochemical marker of AD, is of important and practical value in clinical diagnosis and condition assessment of AD.
Keywords:Alzheimer disease  Dementia  vascular  AD7c-NTP  Enzyme-linked immunosorbent assay  Urine  
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