骨盆漏斗韧带微淋巴管计数在子宫内膜癌中的意义

目的探讨子宫内膜腺癌中骨盆漏斗韧带微淋巴管密度（Micro Lymphatic Vessel Density,MLVD）与淋巴转移之间的关系。推断骨盆漏斗韧带中新生淋巴管在子宫内膜癌淋巴转移中的作用。方法应用免疫组化S-P法,在62例分期不同子宫内膜腺癌患者骨盆漏斗韧带组织标本中用D2-40标记淋巴管,计数微淋巴管密度（MLVD）。结果子宫内膜癌时骨盆漏斗韧带中MLVD与国际妇产科联盟（FIGO）分期Ⅲ/Ⅳ期组比较显著高于FIGO分期Ⅰ/Ⅱ期组,淋巴结转移组LVD高于无淋巴结转移组（P〈0.05）。结论骨盆漏斗韧带MLVD与子宫内膜癌的临床分期、细胞分化程度,浸润子宫肌层深度及淋巴结转移有相关性。

Significance of micro lymphatic vessel density of pelvic funnel ligament in endometrial adenocarcinoma

Objective To study the correlation between micro lymphatic vessel density（MLVD） of pelvic funnel ligament in endometrial adenocarcinoma and lymph node metastasis of endometrial adenocarcinoma and the role of lymphangiogenesis of pelvic funnel ligament in lymphatic metastasis of endometrial carcinoma.Methods Lymphatic vessels in pelvic funnel ligament tissue samples from 62 patients with endometrial adenocarcinoma at different phases were labeled with D2-40 using the immunohistochemistry S-P method to calculate the MLVD.Results The MLVD at Ⅲ and Ⅳ phases in pelvic funnel ligament tissue samples was higher than that at I and Ⅱphases according to the International Obstetrics and Gynecology League Phases（P0.05）.The LVD was higher in patients with lymphatic metastasis than in those without lymphatic metastasis（P0.05）.Conclusion MLVD in pelvic funnel ligament is correlated with the clinical phase,cell differentiation,depth of invasion,and lymphatic metastasis of endometrial carcinoma.