湿疹喷雾剂醇沉纯化工艺的研究

目的:研究湿疹喷雾剂水提醇沉纯化工艺最优条件。方法:以苦参碱含量为评价指标,采用正交设计试验法对湿疹喷雾剂的水提液醇沉工艺进行优化。结果:徐长卿、苦参醇沉最优工艺参数为:水提取液浓缩至药材∶溶剂(g∶mL)为1∶0.57,含醇量70%,醇沉时间12h。结论:该醇沉纯化工艺合理、可行,可为湿疹喷雾剂工业化生产中药材前处理提供依据。

Study on Alcohol Precipitation Techniques for Eczema spray

Objective: To study the optimal conditions of the water extracting and alcohol precipitation techniques for Eczema Spray.Methods: The content of Matrine were used as the assessment markers.The water extracting and alcohol precipitation techniques for Eczema Spray was optimized with orthogonal design experiment.Results: The optimal technological parameters of the alcohol precipitation techniques for Cynanchum paniculatum and Radix sophorae flavescentis were as follows: the ratio between medicinal materials and solvent is 1 to 0.57,the percentage of alcohol is 70%,and the time of alcohol precipitation is 12 hours.Conclusion: The optimized extract conditions are reasonable and feasible,and it provides foundation for pre-preparation of crude material of eczema spray's industrialize production.