双氯芬酸钠巴布剂的制备及体外透皮研究

目的：制备双氯芬酸钠（DCS）的巴布剂，并对其体外释药特性进行考察。方法：制备1％的DCS巴布剂及凝胶剂，考察两者对小鼠离体皮肤的渗透性。结果：与同剂量DCS凝胶相比，DCS巴布剂的离体皮肤累积渗透量及渗透速率均有显著提高（P〈0．05）。结论：DCS巴布剂体外渗透性能优于其凝胶剂，值得进一步研制，以期为DCS新型外用制剂的研制奠定基础。

Study on the Preparation and Transdermal Penetration of Diclofenac Sodium Cataplasm in vitro

Objective ： To study the preparation and transdermal penetration of diclofenac sodium（DCS） cataplasm in vitro. Method ： The DCS cataplasm and DCS gel with the same concentration （ 1% ） were prepared, their transdermal penetration was observed by mouse skin in vitro. Result： Compared with DCS gel, the accumulative penetration amount and penetration rate of DCS cataplasm in vitro were both significantly increased（ P 〈 0.05 ）. Conclusion： DCS cataplasm was better than DCS gel in vitro. It is valuable to be studied further in order to prepare a new kind of DCS external use preparation.