T-Cell Acute Lymphoblastic Leukemia with t(11;14) in Children |
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| Authors: | Raul C. Ribeiro Susana C. Raimondi Frederick G. Behm Ching-Hon Pui |
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| Affiliation: | a Departments of Hematology-Oncology St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USAb Departments of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA |
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| Abstract: | We review and update our examination of the clinical and biologic findings in 19 cases of acute lymphoblastic leukemia (ALL) with the t(11;14) and discuss the literature relevant to the clinical, biologic, and molecular aspects of these translocations. In nine consecutively diagnosed cases at St. Jude Children's Research Hospital and 10 cases reported by other institutions, clinical features did not differ among T-cell ALL patients with and without the t(11;14), although leukemic cells with this translocation were more likely to coexpress CD4 and CD8 antigens. The t(11;14)(p13;q11) appears to occur exclusively in T-cell malignancies of intermediate- or late-stage thymocyte differentiation; further studies will be needed to determine whether it has prognostic significance. |
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| Keywords: | T-ALL,t(11 14),Pediatric ALL,acute leukemia,translocation |
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