| 血清IL-6、TNF-a和SAA水平变化在急性冠脉综合征发病过程中的意义 |
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| 引用本文： | 陈文思,李刚,吴玉叶. 血清IL-6、TNF-a和SAA水平变化在急性冠脉综合征发病过程中的意义[J]. 热带医学杂志, 2006, 6(11): 1207-1208 |
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| 作者姓名： | 陈文思 李刚 吴玉叶 |
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| 作者单位： | 中山大学附属第三医院检验科,广州,510630;中山大学附属第三医院感染科,广州,510630 |
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| 摘 要： | 目的探讨急性冠脉综合征(ACS)患者血清白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)和血清淀粉样蛋白A(SAA)水平变化及临床意义。方法90例ACS患者分成急性心肌梗死(AMI)、不稳定型心绞痛(UAP)、稳定型心绞痛(SAP)三组,50例健康体检人群作为正常对照组,采用酶联免疫吸附试验(ELISA)测定四组血清IL-6、TNF-a、SAA水平。结果三组的ACS患者血清IL-6、TNF-a、SAA水平明显高于正常对照组(P<0.01),其中IL-6和SAA水平在AMI、UAP、SAP三组间均有明显差异(P<0.05)。结论血清IL-6、TNF-a、SAA与ACS患者发病过程的炎症反应关系密切,此三项指标可为临床诊断ACS和分型诊断提供重要依据。
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| 关 键 词： | 白介素-6 肿瘤坏死因子-a 血清淀粉样蛋白A 冠脉综合征 |
| 文章编号： | 1672-3619（2006）11-1207-02 |
| 收稿时间： | 2006-08-13 |
| 修稿时间： | 2006-09-20 |
Clinical Significance of Changes of Serum IL-6,TNF-a and SAA Levels in Patients with Acute Coronary Syndrome |
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| CHEN Wen-si,LI Gang,WU Yu-ye. Clinical Significance of Changes of Serum IL-6,TNF-a and SAA Levels in Patients with Acute Coronary Syndrome[J]. Journal Of Tropical Medicine, 2006, 6(11): 1207-1208 |
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| Authors: | CHEN Wen-si LI Gang WU Yu-ye |
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| Abstract: | Objective To investigate the clinical significance of changes of serum Interleukin-6,Tumor necrosis factor-alpha and Serum Amyloid A levels in Acute coronary Syndrome(ACS).Methods 90 cases of ACS were divided into AMI,UAP and ACS three groups.50 healthy people were used as control.The serum levels of IL-6,TNF-alpha and SAA were measured by ELISA.Results The levels of TL-6,TNF-a and SAA in ACS were obviously higher than those of control(P<0.01).The levels of IL-6 and SAA in AMI,UAP and SAP were significantly different from each other(P<0.05).Conclusion The serum IL-6,TNF-alpha and SAA levels were related with reaction of inflammation in the course of ACS and could be used as markers clinical diagnosis of ACS. |
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| Keywords: | interleukin-6 tumor necrosis factor-alpha serum amyloid A acute coronary syndrome |
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