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鼻息肉组织中CD34的表达及微血管密度的临床意义
引用本文:姚利,李学佩,陆兴,尹为华.鼻息肉组织中CD34的表达及微血管密度的临床意义[J].临床耳鼻咽喉头颈外科杂志,2005,19(20):913-915.
作者姓名:姚利  李学佩  陆兴  尹为华
作者单位:北京大学第三医院耳鼻咽喉科,北京,100038;北京大学深圳医院耳鼻咽喉科
摘    要:目的:探讨CD34在人鼻息肉组织中的表达硬微血管密度(MVD)的临床意义。方法:采用免疫组织化学Elivision Plus二步法,榆测30例止常下鼻甲(对照组)和60例鼻息肉(鼻息肉组)组织中CD34蛋白的表达情况,对CD34阳性血管进行MVD计数,并了解微血管的分布情况。结果:在鼻息肉组织中CD34阳性表达较广泛.在正常下鼻甲组织中CD34呈散在的弱阳性表达。鼻息肉组MVD明显高于对照组(P〈0.01),并且在鼻息肉组中Ⅱ型3期、Ⅲ型中的MVD较Ⅱ型1期显著升高(P〈0.01)。结论:CD34的表达及微血管的增生与鼻息肉的发生、发展有关,对其检测有助于判断鼻息肉的发展趋势,为新的治疗方案的选择提供依据。

关 键 词:鼻息肉  CD34抗原  微血管密度
文章编号:1001-1781(2005)20-0913-03
收稿时间:2005-04-20
修稿时间:2005年4月20日

The significance of microvessel density and CD34 expression in nasal polyps
YAO Li,LI Xuepei,LU Xing,YIN Weihua.The significance of microvessel density and CD34 expression in nasal polyps[J].Journal of Clinical Otorhinolaryngology,2005,19(20):913-915.
Authors:YAO Li  LI Xuepei  LU Xing  YIN Weihua
Institution:Department of Otolaryngology, Third Hospital, Peking University, Beijing, 100083, China.
Abstract:OBJECTIVE: To study the clinicopathologic significance of microvessel density (MVD) and the expression of CD34 in human nasal polyps. METHOD: Using Elivision Plus immunohistochenistry method. Thirty cases of normal inferior turbinate, 60 cases of nasal polyps were stain with CD34. RESULT: MVD of CD34 marker showed higer in the group of nasal polyps than in the group of normal inferior turbinate (P <0.01). MVD in nasal polyps type II phase 3 and type III was higer than that in the nasal polyps type II phasel (P < 0.01). CONCLUSION: MVD iss closely related with the formation edema and development of nasal polyps. Angiogenesis may play an important role in the development of nasal polyps.
Keywords:Nasal polyps  CD34 antigen  Microvessel density
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