| 雄性F344大鼠睾丸间质细胞瘤的癌前期病变及其生物学意义 |
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| 引用本文： | 周光兴,何剑秋,赵为之,佘振珏,杨幼明,杨俊华. 雄性F344大鼠睾丸间质细胞瘤的癌前期病变及其生物学意义[J]. 复旦学报(医学版), 1995, 0(4) |
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| 作者姓名： | 周光兴 何剑秋 赵为之 佘振珏 杨幼明 杨俊华 |
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| 作者单位： | 上海医科大学实验动物部 |
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| 摘 要： | 采用全自动图象分析仪结合ＨＥ染色和免疫组织化学染色，对已有不育史的５个年龄组雄性Ｆ３４４大鼠的睾丸进行形态定量研究及病理形态分析。结果提示：睾丸间质细胞为增生为睾丸间质细胞瘤的癌前期病变，两者对引起雄性Ｆ３４４大鼠不育均有重要意义。
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| 关 键 词： | 睾丸间质细胞瘤，形态定量学，癌前期病变，乳酸脱氢酶同工酶C_4 |
THE SIGNIFICANCE OF THE BIOLOGY OF PRENEOPLASTIC ON MALE FISCHAR 344 RATS WITH TESTICULAR INTERSTITIAL CELL TUMOR |
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| Zhou Guangxing, He Jianqiu, Zhao Weizhi, She Zhenjue,YangYouming,Yang Junhwa. THE SIGNIFICANCE OF THE BIOLOGY OF PRENEOPLASTIC ON MALE FISCHAR 344 RATS WITH TESTICULAR INTERSTITIAL CELL TUMOR[J]. Fudan University Journal of Medical Sciences, 1995, 0(4) |
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| Authors: | Zhou Guangxing He Jianqiu Zhao Weizhi She Zhenjue YangYouming Yang Junhwa |
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| Abstract: | In this paper,the male F344 sterility rats were taken from 5 age group, using morphometric measurements of seminiferous tubulesand immunohistochemical staining with anti-rat lactate dehydrogenase isozyme-C (LDH-C4) taken measure of activity in the testicular. The results showed that very clear differences were found in each age group.The results indicated that interstitial cell hyperplasia and seminiferous tubules atrophy are preneoplasia of testicular interstitial celI tumor and may be considered important causes of the male F344 rats sterility. The male F344 rat for the studying the human testicular interstitial cell tumor is the best animal model iof choice. |
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| Keywords: | testicular interstitial cell tumor morphometry preneoplasia Lactate dehydrogenase isozyme-C_4 |
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