脂肪细胞关联基因与老年肥胖代谢性疾病

肥胖及肥胖代谢综合征作为老年人常见病和合并症目前已不再足某些发达国家或地区的问题，它已经成为全球各个国家都将面l临的重大医学问题和健康问题。而且，肥胖可引发老年代谢性疾病、呼吸系统疾病、心血管系统疾病以及骨关节退行性变、性激素分泌失调、静脉淤滞、深静脉血栓形成及肿瘤的发生和发展等，其潜在的健康影响和生命威胁难以估量，给国家带来的社会问题和经济损失也无法计算。而某些脂肪细胞关联基因及肥胖基因与人类肥胖及肥胖代谢综合征密切相关，因此，对这些肥胖基因表达及关联因素实施有效调控，对控制人类肥胖及肥胖代谢综合征的发生、发展及转归具有重要临床意义。正是基于这些，本文通过对肥胖相关基因及其与相关临床疾病关系的文献进行综述，希望未来能够对以这些肥胖基因作为靶点的肥胖预防和治疗药物的设计提供某些依据并奠定一定基础。

Adipose Cells Associated Genes and the Elderly Obesity- related Metabolic Diseases

As a common geriatric disease and complication, obesity and the metabolic syndrome are no longer the problems of certain developed countries and regions. They have become a serious medical and health problem for all nations of the world. Obesity may cause the elderly metabolic diseases, respiratory system diseases, cardiovascular system diseases, bone and joint degeneration, sex hormones disorders, venous stasis, deep venous thrombosis and various cancers. Its effect upon health and threat towards life should not be underestimated and the social problems and economic losses it brings are beyond calculation. Some fat cells associated genes and obesity genes are closely related to obesity and the metabolic syndrome. Therefore, effective regulation of the expression of obesity genes and associated factors has significant clinical implications for controlling the development and transformation of obesity and the metabolic syndrome. By reviewing relevant literature on obesity associated genes and their relationship with related clinical diseases, this paper hopes to provide basis and lay foundation for the prevention of obesity and designing of treatment medicine that target these obesity genes.