子痫前期患者孕期血脂代谢变化异常的研究

目的探讨子痫前期患者孕前与孕足月血脂代谢异常情况。方法采取回顾性研究方法,针对2011年5月至2013年1月在大连市旅顺口人民医院产科门诊定期行产前检查并住院分娩的孕产妇,选取孕12周前在门诊建册并化验了血脂水平的孕妇,在孕期确诊为子痫前期的孕妇112例为实验组,孕期及孕前无心、肝、肾及内分泌疾病的健康孕妇263例为对照组,记录孕足月,分娩前的血脂水平,与孕12周前血脂水平对比,比较两组间及组内孕期血脂代谢的变化。结果实验组孕12周前TG即明显高于对照组,二者差异有统计学意义(P<0.01),孕足月时实验组的TG水平亦明显高于对照组(P<0.05),也就是说实验组的孕妇在孕期持续保持较高的TG水平。结论子痫前期患者存在血脂代谢调节异常,这种异常从孕早期即有体现,其中血浆三酰甘油(TG)升高与子痫前期的发病有密切关系,因此孕早期监测血脂TG水平,对于早期筛查出子痫前期的潜在患者,并于孕期采取适当措施早期干预,以达到预防子痫前期发病或减轻症状具有重要的临床意义。

Study of Preeclampsia During Pregnancy Abnormal Changes in Lipid Metabolism

Objective Discussion preeclampsia at term pregnancy and pregnancy lipid metabolism abnormalities. Method A retrospective study of methods for May 2011 to January 2013 in Dalian, People＇s Hospital of Port Arthur prenatal obstetric clinic regularly checked and hospital delivery of maternal, select pregnant 12 weeks ago in the clinic and laboratory tests on blood lipids build volumes levels of pregnant women during pregnancy diagnosed 112 cases of pregnant women with pre-eclampsia as the experimental group, pregnancy and pre-pregnancy mood, liver, kidney and endocrine diseases 263 healthy pregnant women as control group, recording full-term pregnancy, blood lipid levels before delivery, and lipid levels before 12 weeks gestation compared between the two groups were compared and changes in lipid metabolism in pregnancy group. Results Experimental group TG ie before 12 weeks of gestation was significantly higher, the difference was statistically significant （P〈0.01）, TG levels full-term pregnancy was also significantly higher in the experimental group （P〈0.05）, which is said pregnant women in the experimental group continued to maintain a high TG levels during pregnancy. Conclusion The presence of preeclampsia abnormal lipid metabolism, this anomaly that is reflected from the first trimester, in which plasma triglyceride （TG） and increased incidence of pre-eclampsia closely, so TG lipid levels in early pregnancy monitoring for early patients with pre-eclampsia screening out potential, and take appropriate measures in pregnancy early intervention in order to achieve the prevention of preeclampsia or alleviate the symptoms has important clinical significance.