| 急性染铅小鼠海马脑片凋亡相关酶活性变化 |
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| 引用本文： | 高明奇,张天彪,孙黎光,金心. 急性染铅小鼠海马脑片凋亡相关酶活性变化[J]. 中国公共卫生, 2005, 21(4): 440-441 |
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| 作者姓名： | 高明奇 张天彪 孙黎光 金心 |
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| 作者单位： | 1. 中国医科大学生物化学与分子生物学教研室,沈阳,110001
2. 中国医科大学87期在校学生 |
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| 基金项目： | 国家自然科学基金资助 (39970 651 ) |
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| 摘 要： | 目的探讨急性铅中毒时小鼠海马钙蛋白酶和钙凋磷酸酶活性的变化及D-2-氨基-5-磷酸基戊酸(D-(-)-2-Amino-5-phosphonopentanoic acid，AP-5)的影响。方法采用离体海马脑片观察急性铅中毒时钙蛋白酶和钙凋磷酸酶活性的变化及AP-5的作用。结果急性铅中毒可致海马钙蛋白酶和钙凋磷酸酶活性增加，AP-5可拮抗铅的这种作用。结论AP-5可拮抗铅引起的海马钙蛋白酶和钙凋磷酸酶活化。
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| 关 键 词： | 铅 海马脑片 钙凋磷酸酶 钙蛋白酶 |
| 文章编号： | 1001-0580(2005)04-0440-02 |
| 修稿时间： | 2005-01-04 |
Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead - poisoned mice |
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| GAO Mingqi,ZHANG Tianbiao,SUN Liguang,et al.. Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead - poisoned mice[J]. Chinese Journal of Public Health, 2005, 21(4): 440-441 |
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| Authors: | GAO Mingqi ZHANG Tianbiao SUN Liguang et al. |
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| Affiliation: | GAO Mingqi,ZHANG Tianbiao,SUN Liguang,et al.Department of Biochemistry and Molecular Biology,Basic Medical College,China Medical university |
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| Abstract: | Objective To explore changes of hippocampal calpain and calcineurin activities in Pb 2+ damaged mouse and effect of (D-(-)-2-Amino-5-phosphonopentanoic acid) AP-5 on it.Methods By means of hippocampal slice to observe changes of calpain and calcneurin activities in mouse.Results Pb 2+ resulted in increases of calpain and calcineurin activities in mouse hippocampal slices,and AP-5 could antagonize preceding changes.Conclusion AP-5 can antagonize the increase of calpain and calcineurin activities of mouse induced by Pb 2+. |
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| Keywords: | lead hippocampal slice calcineurin calpain |
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