Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

ObjectivesThe accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver.MethodsPatients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV–PV samples (6 biomarkers: hyaluronic acid HA], haptoglobin, matrix metalloproteinase-2 MMP2], tissue inhibitor of metalloproteinases-1 TIMP1], procollagen III N-terminal peptide PIIINP], and apolipoprotein-A1 Apo-A1]) were enrolled.ResultsDifferences were displayed between the HV and PV in the predictive logit-models for predicting AF (? 3.13 + 0.017 × MMP2 ? 0.019 × haptoglobin and ? 0.270 + 0.007 × HA ? 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p = 0.03), MMP2 (0.72/0.63, p = 0.04), HA (0.79/0.76, p = 0.94), Apo-A1 (0.56/0.48, p = 0.73), and predictive logit-model (0.81/0.78, p = 0.68) showed higher diagnostic value in the HV sample.ConclusionsWhile most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.