| 微重力环境下MicroRNA调控成骨细胞分化研究进展 |
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| 引用本文： | 张扬,张西正.微重力环境下MicroRNA调控成骨细胞分化研究进展[J].医用生物力学,2018,33(3):285-290. |
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| 作者姓名： | 张扬 张西正 |
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| 作者单位： | 军事医学科学院卫生装备研究所 |
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| 基金项目： | 国家自然科学基金项目（31370942，11432016） |
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| 摘 要： | MicroRNA(miRNA)是生物学过程中基因表达的重要调控分子,但miRNA在骨组织代谢过程中发挥的重要调控作用尚未完全阐明。综述现阶段miRNA在微重力环境下对成骨细胞分化的调控作用,对miRNA的调控作用分为正负两类分别进行归纳,重点介绍不同基因的作用机制,并列举在微重力环境下对骨组织代谢有重要影响的一些miRNA分子。微重力环境下miRNA对骨组织代谢性疾病具有比较重要的调控作用,其相关研究对预防及治疗失重性骨质缺失病症意义重大。
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| 关 键 词： | 微小RNA 微重力环境 成骨细胞 骨代谢 调控机制 |
| 收稿时间： | 2017/5/8 0:00:00 |
| 修稿时间： | 2017/6/26 0:00:00 |
Research Progress on MicroRNA Regulating Osteoblast Differentiation under Microgravity |
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| ZHANG Yang and ZHANG Xizheng.Research Progress on MicroRNA Regulating Osteoblast Differentiation under Microgravity[J].Journal of Medical Biomechanics,2018,33(3):285-290. |
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| Authors: | ZHANG Yang and ZHANG Xizheng |
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| Institution: | Institute of Medical Equipment, Academy of Military Medical Sciences and Institute of Medical Equipment, Academy of Military Medical Sciences |
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| Abstract: | MicroRNA (miRNA) is a kind of important gene expression regulatory molecules during biological process, but its regulation mechanism in metabolic process of bone tissues has not been completely clarified. In this review, the regulation of miRNA on osteoblast differentiation in microgravity environment was discussed. The positive and negative regulation of miRNA was summarized, respectively, with focus on introducing the mechanism of different genes. Some miRNA molecules that have important effects on bone metabolism under microgravity were enumerated. MiRNA plays an important role in regulating and controlling bone metabolic diseases in microgravity environment, and its related studies are significant for the prevention and treatment of bone loss induced by weightlessness. |
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| Keywords: | microRNA(miRNA) microgravity osteoblasts bone metabolism regulation mechanism |
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