胃癌患者根治术后早期肠内营养的临床疗效观察

目的探索进展期胃癌患者根治术后行早期肠内营养（enteral nutrition，EN）的疗效和安全性。方法选择2008年12月至2013年4月期间内蒙古医科大学附属医院收治的70例行根治性手术的进展期胃癌患者，将患者随机分为EN组35例和肠外营养（parenteral nutrition，PN）组35例，记录并比较2组患者的营养指标和康复指标。结果术前2组患者的白细胞计数、血浆清蛋白（ALB）、前清蛋白（PA）及转铁蛋白（TRF）水平比较差异均无统计学意义（P〉0．05）；术后3d和7d，除白细胞计数为EN组低于PN组外（P〈0．05），ALB、PA及TRF水平均是EN组高于PN组（P〈0．05）。EN组患者的术后住院时间和住院费用均短于或低于PN组（P〈0．05），而2组患者的术后排气时间和并发症发生率比较差异均无统计学意义（P〉0．05）。结论EN是一种安全、有效及经济的营养补给方法，是进展期胃癌患者术后早期首选的营养支持方法，值得在临床推广。

Clinical Efficacy of Early Enteral Nutrition on Patients with Gastric Cancer after Radical Operation

Objective To explore the clinical efficacy and security of early enteral nutrition （EN） on patients with gastric cancer after radical operation. Methods Seventy cases who treated in Affiliated Hospital of Inner Mongolia Medical University from Dec. 2008 to Apr. 2013 were randomly divided into EN group （n=35） and parenteral nutrition （PN） group （n=35）, analysis and comparison of nutrition indicators and recovery indicators between 2 groups were performed. Results There were no significant differences on levels of count of white blood cell （WBC）, serum albumin （ALB）, prealbumin （PA）, and transferring （TRF） before operation between the 2 groups （P〉 0. 05）. On 3 and 7 days after operation, the levels ofALB, PA, and TRF were all higher in EN group （P〈 0. 05） besides level of count of WBC. In addition, hospital stay and hospitalization cost were both lower in EN group （P 〈 0. 05）, but there was no significant difference on postoperative exhaust time and complication incidence （P〉0.05）. Conclusion EN is a safe, effective, and economical method of nutritional supplements, and it is a preferred method of nutritional support for patients with advanced gastric cancer after operation at prophase, which is worthy to apply widely in clinical.