Ki-67抗原与乳腺癌的相关性研究

目的探讨Ki-67抗原在乳腺癌组织中的表达，并评价其表达与乳腺癌生物学行为及判断乳腺癌预后的关系。方法检索近年来有关Ki-67与乳腺癌的相关性研究的文献并做综述。结果Ki-67在乳腺癌组织中的表达水平显著高于癌旁组织及正常乳腺组织，且Ki-67表达阳性率与乳腺癌病理分级、临床分期呈正相关，而Ki-67表达与乳腺癌腋窝淋巴结转移的相关性研究结果不尽一致。结论Ki-67抗原是与细胞增殖周期相关的细胞核抗原，其表达随细胞周期的变化而变化，是检测细胞增殖活性较为可靠的标志物，其可能成为判断肿瘤恶性程度及评估预后的重要指标；Ki-67表达水平的检测在乳腺肿瘤的早期诊断、指导新辅助化疗、评估预后等方面有重要意义。

Correlative Research of Ki-67 Antigen in Breast Cancer

Objective To explore the expression of Ki-67 antigen in the breast cancer tissues and to evaluate the relationship of the expression to biology behavior as well as prognosis of breast cancer. Method Literatures about relation between Ki-67 and breast cancer were reviewed. Results The expression of Ki-67 in the breast cancer tissue was obviously higher than that in the adjacent to cancer tissue or normal breast tissue. The Ki-67 positive expression rate was positively correlated with pathology classification and clinical stage of breast cancer, the correlation was not consistent about the expression of Ki-67 and axillary lymph node metastasis of breast cancer. Conclusions Ki-67 is a cell proliferation nuclear antigen related to cell cycle , and its expression changes along with the change of cell cycle, it has been employed as a reliable marker of cell proliferation. The expression of Ki-67 has an important significance in early diagnosis and guiding of neoadjuvant chemotherapy as well as prognosis of breast cancer.