CyclinD1在不同分子亚型乳腺癌中的表达及其对预后的影响

目的检测cyclinD1在不同分子亚型乳腺癌中的表达，分析其表达与临床病理特征和预后的关系。方法采用免疫组织化学法检测175例乳腺癌组织标本中cyclinD1的表达情况，应用卡方检验分析cyclinD1在不同分子亚型乳腺癌中的表达，采用Spearman秩相关方法分析cyclinD1表达与临床病理特征的相关性，运用Kaplan．Meier生存曲线分析cyclinD1不同表达对预后的影响。结果①CyclinD1阳性表达在LuminalA型所占比例最高（P〈0．05），而cyclinDI阴性表达在LuminalB型所占比例最高（P〈0．05）。②CyclinD1阳性表达与临床分期、组织学分级及PR无关（P〉0．05），与淋巴结转移数目（rs=0．197，P〈0．01）、ER呈正相关（rs=0．139，P〈0．05）；cyclinD1阳性表达与Her-2呈负相关（rs=0．131，P〈0．05）。③CyclinD1阳性表达越强，无瘤生存时间越长（P〈0．05）。结论CyclinD1阳性表达与ER、Her-2及淋巴结转移数目有明显相关性，且其阳性表达提示相对良好的预后，可作为乳腺癌预后评估的参考指标。

Expression of Cyclin D1 in Different Molecular Subtypes of Breast Cancer and Its Impact on Prognosis

Objective To detect the expression of cyclin D1 in different kinds of clinical molecular subtypes of breast cancer tissue, and to analyze the relationships of the expression to clinicopathologic characteristics and prognosis. Methods The expression ofcyclin D1 was detected in 175 cases of different kinds of clinical molecular subtypes of breast cancer by immunohistochemical method. The expression was compared among different kinds of clinical molecular subtypes of breast cancer by chi-square test. The correlations with clinicopathologic characteristics were analyzed by Spearman rank correlation. The impact of different expression of cyclin D1 on the prognosis was analyzed by the Kaplan- Meier survival curve. Results ① In the positive expression group of cyclin D 1 in the breast cancer, Luminal A type was the highest proportion （P〈0. 05） ; but in the negative expression group of cyclin D1 in the breast cancer, Luminal B type was the highest proportion （P〈0.05）. ② The expression of cyclin D1 had no correlation with clinical stage, histological grade or PR （P〉0. 05）, was positively correlated with number of lymph node metastasis （rs=0. 197, P〈0. 01） or ER （rs=0. 139, P〈 0. 05）, was negatively correlated with Her-2 （rs=-0. 131, P〈 0. 05）. ③ The positive expression of cyclin D1 was stronger, the tumor free survival time was longer （P〈 0. 05）. Conclusion This study shows that there is a correlation between the positive expression of cyclin D1 and ER, Her-2, or number of lymph node metastasis, and its oositive exoression oromDts a relatively good oromaosis, can be used as the Drowaosis indicator for breast cancer.