A randomized study on the effects of intramuscular injections with urinary gonadotrophins (Humegon or Pergonal) on pain, local redness and fever in infertile women opting for in-vitro fertilization

The objective of this open, multicentre, randomized controlled study inwomen opting for in-vitro fertilization was to compare the occurrence ofpain and redness at the injection site and of post-injection fever afteri.m. injection with Humegon (n = 89) or Pergonal (n = 92). Assessments werescoring of pain and redness at the injection site and of post-injectionfever during the next 24 h using self-administered questionnaires.Injection site pain was reported in 48.9% of injections with Humegon and in44.9% with Pergonal (P = 0.45). A trend was seen towards more redness afterPergonal injection (24.0 versus 15.5%; P = 0.08). Post-injection fever wasreported in 1.4% with Humegon and in 1.1% with Pergonal (P = 0.80). It wasconcluded that there are no statistically significant differences betweenHumegon and Pergonal after i.m. injection with respect to the prevalence ofpain and redness at the injection site and of post-injection fever.